The importance of O-GlcNAcylation in maintaining normal cell function in mammalian organisms has en demonstrat by the three lines of evidence. 1. Mechanistically, protein O-GlcNAcylation, primarily regulat by OGT and OGA levels and activities, can regulate gene transcription and proteasomal activities, as well as autophagy (Wells et al., 2001; Zhang […]
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