We ne this not only for our mission to treat age-associat diseases broadly, but also simply to yield critability to our field. Here, our new open access journal Frontiers in Aging may come a key outlet for this research. So, Where Do We Go From Here? Twenty years ago, the […]
The use of small molecules as potential geroprotectors and/or pharmacogenomics in model organisms has gain considerable attention. Some of the most promising molecules in this regard point to nicotinamide adenine dinucleotide (NAD) and its precursors. Due to the rare applicability of genetic techniques in ameliorating aging progression in humans, it […]
Human aging has en associat with a decline in biological resilience and the risk of diseases grows exponentially over time, depending on heritary, environmental factors, lifestyle, mental health, and stochastic factors. Despite this fact, old age does not necessarily result in poor health and not all age-relat changes are maladaptive. […]
In mice with the specific goal of translating the findings to clinical trials in humans (Warner et al., 2000). The program, which investigates the lifespan effect of propos interventions in genetically diverse mice across multiple centers, has en a massive success with numerous groundbreaking findings perhaps most notoriously the discovery […]
To start histogenesis and organogenesis, the activity of a certain part of the IntG is requir, which is accompani by epigenetic downregulation of HG, part responsible for complete autonomy (toti and pluripotency). Such a “chain reaction” of IntG and HG activity, not only allows the cells (and tissues and organs […]
This main consequence of the ontogenesis, inevitably leads to the degradation resulting in organism aging.Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults Laura Haynes UConn Center on Aging, University of Connecticut School of Micine, Farmington, CT, Unit States The world’s population is aging, […]
The miators of this systemic inflammation are pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor alpha, which increase with increasing age (Bruunsgaard, 2006; Maggio et al., 2006). This chronic inflammation is a highly significant risk factor for both morbidity and mortality in older adults (Franceschi et al., 2000) and […]
Recent studies have shown that clearance of these senescent cells in transgenic mouse models or by senolytic drug treatment can alleviate senescence-associat disease states (Xu et al., 2015; Xu et al., 2018). In addition, a 2019 study has also shown that deletion of senescent cells enhances T-cell proliferation (Palacio et […]
Additionally, chronic infections such as CMV infections contribute to the accumulation of highly differentiat memory CD8 T cells that exhibit characteristics of replicative senescence (Ouyang et al., 2003; Pawelec and Gouttefangeas, 2006). The age-relat accumulation of these terminally differentiat CD8 T cells serves to constrict the immune repertoire and has […]
Vaccinations are strongly recommend for older adults to protect them from both influenza and bacterial pneumonia, but cause of age-relat changes in immune function, vaccine efficacy and effectiveness decline with age (Ciabattini et al., 2018). Further understanding of how aging of the immune system results in increas susceptibility to infectious […]
Aging is not as static as it once seem. Clearly, we now know that several conserv molecular changes occur in organisms with age and we have develop interventions in animal models to impact almost all of them. Nevertheless, despite our great push for testing life- and healthspan altering molecules and […]
If you are prict to older than your real chronological age you have a higher overall mortality risk. Since some people appear to age faster than others, the prict age from these algorithms is thought to more closely resemble the true biological age of a person. And we can then […]
