In mice with the specific goal of translating the findings to clinical trials in humans (Warner et al., 2000). The program, which investigates the lifespan effect of propos interventions in genetically diverse mice across multiple centers, has en a massive success with numerous groundbreaking findings perhaps most notoriously the discovery that rapamycin extends the lifespan of mice (Harrison et al., 2009). Nevertheless, the hope of real translation was never completely carri forward to humans even though some trials have en examining the effect of compounds such as rapamycin on age-associat diseases, but not aging itself.
Whole Organism Changes That Underlie
To tackle our grand challenge, I propose that the field funds a human interventions testing program that will investigate promising compounds in humans. In my opinion, the human interventions testing program should design in a similar way as the ITP with multiple cohorts across geographically and ethnically diverse populations. Given Japan Email List that we have highly accurate biomarkers cohorts can small, perhaps as little as 50 individuals per cohort and a treatment time of 6 months after which the intervention should evaluat perhaps with a composite biomarker. If an effect is observ, another 6 months will add to the treatment time and another evaluation will perform. If an effect is still observ another 6 months treatment will perform etc. Importantly, following this scheme should allow the evaluation of interventions perhaps even faster than the ITP.
With Aging Phenotypes Will Likely Reveal
Obviously, this is simply a possible trial design and others are undoubtly at least as valuable. The important notion is that we start translation to humans. Should We Forget Other Models? No! As is the case in the pharmaceutical industry, mice, and other animal models are critical for preclinical development and mechanistic investigations. We will still ne our continuous focus on the basic biology of aging and testing of interventions for safety and pharmacological reasons. Evidently, we are still not able to stop aging in mice or any other organism and significant areas within the biology of aging remain unchart. I therefore TH Lists encourage you, dear reader, to submit any intervention study regardless of species to our open access journal.Lifespan is increasing worldwide, but health span has not shown a similar rate.
