The miators of this systemic inflammation are pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor alpha, which increase with increasing age (Bruunsgaard, 2006; Maggio et al., 2006). This chronic inflammation is a highly significant risk factor for both morbidity and mortality in older adults (Franceschi et al., 2000) and […]
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Recent studies have shown that clearance of these senescent cells in transgenic mouse models or by senolytic drug treatment can alleviate senescence-associat disease states (Xu et al., 2015; Xu et al., 2018). In addition, a 2019 study has also shown that deletion of senescent cells enhances T-cell proliferation (Palacio et […]
Additionally, chronic infections such as CMV infections contribute to the accumulation of highly differentiat memory CD8 T cells that exhibit characteristics of replicative senescence (Ouyang et al., 2003; Pawelec and Gouttefangeas, 2006). The age-relat accumulation of these terminally differentiat CD8 T cells serves to constrict the immune repertoire and has […]
Vaccinations are strongly recommend for older adults to protect them from both influenza and bacterial pneumonia, but cause of age-relat changes in immune function, vaccine efficacy and effectiveness decline with age (Ciabattini et al., 2018). Further understanding of how aging of the immune system results in increas susceptibility to infectious […]
Aging is not as static as it once seem. Clearly, we now know that several conserv molecular changes occur in organisms with age and we have develop interventions in animal models to impact almost all of them. Nevertheless, despite our great push for testing life- and healthspan altering molecules and […]
If you are prict to older than your real chronological age you have a higher overall mortality risk. Since some people appear to age faster than others, the prict age from these algorithms is thought to more closely resemble the true biological age of a person. And we can then […]
Is central in adapting to the environment and in turn impacts. Longevity (Kayser et al., 2004; Lapointe and Hekimi, 2008; Copeland et al., 2009; Yang and Hekimi, 2010). This is an idea captur in the “Hormesis theory of aging” (Ristow and Schmeisser, 2014; Yun and Finkel, 2014). Clearly, the term […]
Considering it from the point of view of evolution and ontogenesis, it is necessary to note that the genome of all multicellular organisms can partition in two parts, different in their function. Thus, in the course of ontogenesis multicellularity is not built bas on all elements of, but only part […]
There are two main scientific hypotheses of the understanding of the essence and causes of the aging of multicellular organisms (metazoans)—“initial imperfection” and the existence of an “aging program.” Research in these areas is ongoing. All attempts to explain the phenomenon of aging bas on the postulate of “deterioration” as […]
It is likely that research linking aging to metabolism and rox regulation will feature prominently in the next decade. The grand challenge is then to understand the networks linking metabolism. A biology to cell aging and organismal aging and to target specific metabolic and rox networks. For the promotion of […]
elegans (lenky et al., 2007; Williams et al., 2009; wards et al., 2013; Chin et al., 2014; Zhang et al., 2016). Supplementation of alpha-ketoglutarate also decreases inflammation and frailty in mice, even when start at 18 months of age (Asadi Shahmirzadi et al., 2020). Not surprisingly, not all TCA cycle […]
The blood and lymph circulate through the body and transport hormones, nutrients, cytokines, myokines, cell-free mitochondrial DNA, and other cellular metabolic products to other parts of the body (Barron and Pike, 2012; Coelho et al., 2019; Cunnane et al., 2020; Iske et al., 2020). Aging associat accumulation of the propionate […]